Our motivated team of researchers.
The Suvà laboratory is focused on the biology of brain tumors, in particular diffuse gliomas in adults and children. We dissect how cellular heterogeneity and plasticity contribute to tumor properties. We study primary human samples at single-cell resolution and establish genetically and epigenetically relevant cellular models from patient tumors. We model how brain cancer cells exploit their plasticity to establish distinct epigenetic programs. We seek to identify common programs that would offer novel therapeutic options in these dismal diseases.
We currently have 3 lines of investigation.
We are leading large-scale efforts in single-cell transcriptional profiling in clinical gliomas in adults with our collaborators at the Broad Institute. These efforts
Our previous work has identified four neurodevelopmental transcription factors as master regulators of a stem-like state in glioblastoma. Our network model currently
Bulk genomic analyses and expression profiling of clinical specimens have shaped much of our understand- ing of cancer in patients. However, human tumors are intricate
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a
Tumor subclasses differ according to the genotypes and phenotypes of malignant cells as well as the composition of the tumor microenvironment (TME). We dissected these
Although human tumours are shaped by the genetic evolution of cancer cells, evidence also suggests that they display hierarchies related to developmental pathways and
Human cancers are complex ecosystems composed of cells with distinct phenotypes, genotypes, and epigenetic states, but current models do not adequately reflect tumor
Developmental fate decisions are dictated by master transcription factors (TFs) that interact with cis-regulatory elements to direct transcriptional programs. Certain