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    Welcome to the Suvà Lab

    The Suvà laboratory is located in the Department of Pathology at Mass. General Hospital and Harvard Medical School. We study human gliomas, integrating genetic, epigenetic and transcriptional informations at the single-cell level to reconstruct cell circuitries and highlight novel dependencies.

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    Suvà Lab Members

Group members

Our motivated team of researchers.

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    Mario L. Suvà

    M.D., Ph.D., Principal Investigator

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    Mariella Filbin

    M.D., Ph.D., Post-doctoral Fellow

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    Christine Hebert

    Research Technician

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    Cyril Neftel

    Graduate student, M.D. Ph.D program

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    Shawn Gillespie

    Research Technologist

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    McKenzie Shaw

    Lab Manager

Research

The Suvà laboratory is focused on the biology of brain tumors, in particular glioblastoma and oligodendroglioma. We dissect how cellular heterogeneity and plasticity contribute to tumor properties. We study primary human samples up to single-cell resolution and establish genetically and epigenetically relevant cellular models from patient tumors. We model how brain cancer cells exploit their plasticity to establish distinct epigenetic programs. Additionally, the laboratory investigates how genetic events affecting genes involved in chromatin regulation rewire cancer cells identities to contribute to cellular transformation. We seek to identify common programs that would offer novel therapeutic options in these dismal diseases.

 

Projects

We currently have 3 lines of investigation.

Featured Publications

 

Full publication list

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