Annotation of functional genomic elements in gliomas

July 22, 2014

We have previously performed deep chromatin landscape profiling and analysis of primary glioblastoma models and have utilized this information to reconstruct functionally validated network models. We are applying these novel technologies to genetically defined primary cultures of IDH1 mutant glioblastoma, H3F3A mutant pediatric glioblastoma and IDH1 mutant oligodendroglioma obtained through our collaborations with the MGH Brain Tumor Center.