Inhibitory CD161 receptor identified in glioma-infiltrating T...
T cells are critical effectors of cancer immunotherapies, but little is known about their gene expression programs in diffuse gliomas. Here, we leverage single-cell RNA
An Integrative Model of Cellular States, Plasticity,...
Diverse genetic, epigenetic, and developmental programs drive glioblastoma, an incurable and poorly understood tumor, but their precise characterization remains
Resolving medulloblastoma cellular architecture by single-cell genomics.
Medulloblastoma is a malignant childhood cerebellar tumour type that comprises distinct molecular subgroups. Whereas genomic characteristics of these subgroups are well
Developmental and oncogenic programs in H3K27M gliomas...
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a
Decoupling genetics, lineages, and microenvironment in IDH-mutant...
Tumor subclasses differ according to the genotypes and phenotypes of malignant cells as well as the composition of the tumor microenvironment (TME). We dissected these
Single-cell RNA-seq supports a developmental hierarchy in...
Although human tumours are shaped by the genetic evolution of cancer cells, evidence also suggests that they display hierarchies related to developmental pathways and