Featured Publications
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Inhibitory CD161 receptor identified in glioma-infiltrating T...
T cells are critical effectors of cancer immunotherapies, but little is known about their gene expression programs in diffuse gliomas. Here, we leverage single-cell RNA
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An Integrative Model of Cellular States, Plasticity,...
Diverse genetic, epigenetic, and developmental programs drive glioblastoma, an incurable and poorly understood tumor, but their precise characterization remains
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Resolving medulloblastoma cellular architecture by single-cell genomics.
Medulloblastoma is a malignant childhood cerebellar tumour type that comprises distinct molecular subgroups. Whereas genomic characteristics of these subgroups are well
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Developmental and oncogenic programs in H3K27M gliomas...
Gliomas with histone H3 lysine27-to-methionine mutations (H3K27M-glioma) arise primarily in the midline of the central nervous system of young children, suggesting a
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Decoupling genetics, lineages, and microenvironment in IDH-mutant...
Tumor subclasses differ according to the genotypes and phenotypes of malignant cells as well as the composition of the tumor microenvironment (TME). We dissected these
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Single-cell RNA-seq supports a developmental hierarchy in...
Although human tumours are shaped by the genetic evolution of cancer cells, evidence also suggests that they display hierarchies related to developmental pathways and
